Strongwater S L, Annesley T, Schnitzer T J
J Rheumatol. 1983 Jun;10(3):459-63.
Polymyositis (PM) is a myopathic syndrome that results in pathology believed to be primarily confined to skeletal muscle. Several recent reports, based on quantitative determinations of total serum creatine kinase (CK) and MB isoenzyme activity, accepted serologic correlates of active myocardial injury, suggest that cardiac involvement in PM may occur more frequently than has been clinically appreciated. We retrospectively studied 12 patients with PM; 83% (10) were found to have substantial elevations in CK-MB activity, often to levels exceeding those seen with myocardial infarctions, thus confirming a high probability of myocardial involvement in PM. Failure to detect this clinically may be indicative of the insensitivity of current technology. A review of the literature substantiates the importance of appreciating the spectrum, frequency and functional consequences (i.e., conduction disturbances, cardiomyopathy) of myocardial involvement in PM.
多发性肌炎（PM）是一种肌病综合征，其病理改变据信主要局限于骨骼肌。最近有几份基于血清总肌酸激酶（CK）和MB同工酶活性定量测定的报告，这些报告认可了与活动性心肌损伤相关的血清学指标，提示PM患者心脏受累的发生率可能比临床认识到的更高。我们对12例PM患者进行了回顾性研究；发现83%（10例）患者的CK-MB活性大幅升高，常超过心肌梗死患者的水平，从而证实PM患者心肌受累的可能性很大。临床上未能检测到这一点可能表明当前技术不够灵敏。文献综述证实了认识PM患者心肌受累的范围、频率及功能后果（即传导障碍、心肌病）的重要性。
