Spiera H, Rothenberg R R
J Rheumatol. 1983 Jun;10(3):464-6.
Four patients with chronic systemic lupus erythematosus (SLE) in whom myocardial infarction occurred at an unusually early age are described. The evidence suggests that the coronary occlusion was due to atherosclerosis. There was no evidence that active arteritis played any role. The only risk factor for atherosclerotic disease was hypertension. All patients had had both central nervous system and renal disease and had been taking corticosteroids for a minimum of 9 years. It is suggested that hypertension aggravated by chronic corticosteroid administration may be an important risk factor for atherosclerosis in patients with SLE.
本文描述了4例慢性系统性红斑狼疮（SLE）患者，他们在异常年轻的年龄发生了心肌梗死。证据表明冠状动脉闭塞是由动脉粥样硬化引起的。没有证据表明活动性动脉炎起了任何作用。动脉粥样硬化疾病的唯一危险因素是高血压。所有患者都有中枢神经系统和肾脏疾病，并且至少服用皮质类固醇9年。有人提出，长期服用皮质类固醇加重的高血压可能是SLE患者动脉粥样硬化的重要危险因素。
