Branch R A, Salih S Y, Homeida M
Clin Pharmacol Ther. 1978 Sep;24(3):283-6. doi: 10.1002/cpt1978243283.
The kinetic disposition of antipyrine following oral administration of 1,200 mg has been investigated in 11 normal Sudanese subjects living in Sudan, 9 Sudanese subjects living in England for at least 2 yr, and 19 normal English subjects living in England. Sudanese subjects living in Sudan had significantly lower mean antipyrine clearance and higher volume of distribution than the English group (-28% and +30%, respectively). There was no significant difference for antipyrine clearance between English and Sudanese subjects living in England, but the volume of distribution of antipyrine was higher (16%) in the Sudanese subjects. The mean half-lives of the three groups differed significantly. We conclude that differences in disposition of antipyrine between native English and Sudanese populations was predominantly due to environmental factors.
对11名居住在苏丹的正常苏丹受试者、9名在英国居住至少2年的苏丹受试者以及19名居住在英国的正常英国受试者口服1200毫克安替比林后的动力学处置情况进行了研究。居住在苏丹的苏丹受试者的安替比林平均清除率显著低于英国组，分布容积则高于英国组（分别低28%和高30%）。居住在英国的英国受试者和苏丹受试者之间的安替比林清除率无显著差异，但苏丹受试者的安替比林分布容积更高（高16%）。三组的平均半衰期有显著差异。我们得出结论，英国本土人群和苏丹人群之间安替比林处置的差异主要归因于环境因素。
