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苏丹肝脾型血吸虫病中的药物代谢：一项关于安替比林的研究。

Drug metabolism in hepatosplenic schistosomiasis in the Sudan: a study with antipyrine.

作者信息

Homeida M, Salih S Y, Branch R A

出版信息

Gut. 1978 Sep;19(9):808-11. doi: 10.1136/gut.19.9.808.

DOI:10.1136/gut.19.9.808
PMID:710970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412193/
Abstract

The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with normal controls. We conclude that antipyrine disposition is normal in patients with clinically compensated hepatosplenic schistosomiasis.

摘要

对10例经组织学确诊为肝脾型血吸虫病的患者和11名居住在苏丹的正常受试者口服1200毫克安替比林后的处置情况进行了研究。与正常对照组相比，患者中通过安替比林清除率评估的药物代谢活性相似。我们得出结论，临床代偿性肝脾型血吸虫病患者的安替比林处置情况正常。

相似文献

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Drug metabolism in hepatosplenic schistosomiasis in the Sudan: a study with antipyrine.苏丹肝脾型血吸虫病中的药物代谢：一项关于安替比林的研究。
Gut. 1978 Sep;19(9):808-11. doi: 10.1136/gut.19.9.808.
2
Altered drug metabolism in hepatosplenic schistosomiasis.
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Propranolol disposition in patients with hepatosplenic schistosomiasis.心得安在肝脾型血吸虫病患者体内的处置情况。
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[Intestinal absorption in the hepatosplenic form of schistosomiasis mansoni].
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[Plasma clearance of bromsulphalein in patients with the hepatosplenic form of schistosomiasis mansoni].
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The pharmacokinetics of antipyrine in patients with graded severity of schistosomiasis.不同严重程度血吸虫病患者中安替比林的药代动力学
Br J Clin Pharmacol. 1985 Oct;20(4):313-6. doi: 10.1111/j.1365-2125.1985.tb05069.x.
5
Propranolol disposition in patients with hepatosplenic schistosomiasis.心得安在肝脾型血吸虫病患者体内的处置情况。
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本文引用的文献

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The fate of antipyrine in man.安替比林在人体内的代谢情况。
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PORTAL HEMODYNAMICS AND LIVER CELL FUNCTION IN HEPATIC SCHISTOSOMIASIS.肝血吸虫病的门静脉血流动力学与肝细胞功能
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Determinants of serum antipyrine half-lives in patients with liver disease.肝病患者血清安替比林半衰期的决定因素。
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Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration.口服和静脉注射后安替比林、甲苯磺丁脲和华法林的血浆水平比较。
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Infection with Schistosoma mansoni in the Gezire area of the Sudan.苏丹杰济拉地区曼氏血吸虫感染情况。
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Mutagenic activities in vitro and in vivo of five antischistosomal compounds.
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