Lin K M, Lau J K, Smith R, Phillips P, Antal E, Poland R E
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509.
Psychopharmacology (Berl). 1988;96(3):365-9. doi: 10.1007/BF00216063.
Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and longer t1/2 under both testing situations. When body surface area was used as a covariate, these cross-ethnic differences remained statistically significant (except Cmax) after oral but not IV drug administration. There were no differences between the two Asian groups in any of these parameters examined in this study. These results confirmed previous observations of ethnic differences in the pharmacokinetic response between Asians and Caucasians and suggested that smaller doses of alprazolam may be required for Asians for similar clinical effects as compared to their Caucasian counterparts.
在42名正常男性志愿者（14名高加索人、14名在美国出生的亚洲人以及14名在国外出生的亚洲人）中，研究了小剂量（0.5毫克）阿普唑仑经口服和胃肠外（静脉注射）给药后的单剂量药代动力学。在两种测试情况下，亚洲人的Cmax显著更高、AUC更大、CL更慢且t1/2更长。当以体表面积作为协变量时，经口服而非静脉给药后，这些跨种族差异在统计学上仍然显著（Cmax除外）。在本研究中所检测的任何参数方面，两个亚洲人群组之间均无差异。这些结果证实了之前关于亚洲人和高加索人药代动力学反应存在种族差异的观察结果，并表明与高加索人相比，亚洲人可能需要更小剂量的阿普唑仑才能产生相似的临床效果。
