Wilson J W, Morales A, Bruce A W
J Urol. 1983 Sep;130(3):481-3. doi: 10.1016/s0022-5347(17)51260-4.
Histological grading and pathological staging are relevant factors in the prognosis of patients with prostatic cancer. Of 115 consecutive patients with carcinoma of the prostate that was staged fully before treatment 16 had stage A2 disease. Low grade neoplasms were present in 6 of these patients and evidence of nodal metastases was documented at lymphadenectomy in 2. Similarly, 4 of 35 patients with low grade stage B1 disease had nodal metastases. With the enzymatic and/or radioimmunoassay techniques for acid phosphatase determination we were unable to select those patients with nodal metastases. From these studies we believe that low grade, low stage carcinoma of the prostate retains a potential for metastatic disease and that acid phosphatase determinations are unreliable in detecting bulky regional nodal involvement.
组织学分级和病理分期是前列腺癌患者预后的相关因素。在115例治疗前已完全分期的前列腺癌连续患者中，16例患有A2期疾病。其中6例患者存在低级别肿瘤，2例在淋巴结切除术中记录有淋巴结转移证据。同样，35例低级别B1期疾病患者中有4例有淋巴结转移。使用酶法和/或放射免疫测定技术测定酸性磷酸酶，我们无法筛选出有淋巴结转移的患者。从这些研究中我们认为，低级别、低分期的前列腺癌仍有发生转移性疾病的可能，并且酸性磷酸酶测定在检测大量区域淋巴结受累方面并不可靠。
