Hisazumi H, Misaki T, Miyoshi N
J Urol. 1983 Oct;130(4):685-7. doi: 10.1016/s0022-5347(17)51403-2.
Photoradiation therapy, in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 46 superficial bladder tumors in 9 patients. A fluorospectrophotometric study of biopsies from these tumors and normal mucosa revealed preferential hematoporphyrin derivative localization in malignant tissues. The tumor response was confirmed ultrasonographically in 36 stages Ta to Tl tumors. Treatment with 100 to 250 J./cm.2 obtained complete remission in 5 of 6 patients with tumors 1 cm. in size or less. For those with tumors up to 2 cm. in size the light intensity should be 300 mw./cm.2 for 5 to 10 minutes or more and the accumulated energy intensity of light dose should be 100 J./cm.2 or more. No patient with tumors more than 2 cm. in size had a complete remission.
对9例患者的46个浅表膀胱肿瘤进行了光辐射治疗，其中血卟啉衍生物由氩离子染料激光激活。对这些肿瘤和正常黏膜活检组织进行的荧光分光光度研究显示，血卟啉衍生物在恶性组织中优先定位。超声检查证实了36例Ta至T1期肿瘤的肿瘤反应。用100至250焦耳/平方厘米的剂量治疗，6例肿瘤大小为1厘米或更小的患者中有5例完全缓解。对于肿瘤大小达2厘米的患者，光强度应为300毫瓦/平方厘米，持续5至10分钟或更长时间，光剂量的累积能量强度应为100焦耳/平方厘米或更高。肿瘤大小超过2厘米的患者无一例完全缓解。
