使用一种新型肿瘤成像剂——铟 - 111标记的卟啉，对荷瘤仓鼠进行全身放射自显影。

Whole-body autoradiography of tumor-bearing hamsters with a new tumor imaging agent, indium-111-labeled porphyrin.

作者信息

Yamazaki K, Hirata S, Nakajima S, Kubo Y, Samejima N, Sakata I

机构信息

First Department of Surgery, Asahikawa Medical College.

出版信息

Jpn J Cancer Res. 1988 Jul;79(7):880-4. doi: 10.1111/j.1349-7006.1988.tb00051.x.

DOI:10.1111/j.1349-7006.1988.tb00051.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917598/

Abstract

We have synthesized a new tumor imaging agent, 111In-labeled porphyrin (111In-ATN-2). In order to image transplantable pancreatic carcinoma in Syrian golden hamsters, we investigated the biodistribution of 111In-ATN-2 72 hr after injecting the agent by means of whole-body autoradiography. The efficacy of the agent was compared with that of 67Ga citrate. The images with 111In-ATN-2 were found to be clearer than those with 67Ga citrate. Tumor-to-tissue radiodistribution ratios of the former were higher than those of the latter. Thus, 111In-ATN-2 seems to be more useful for tumor diagnosis.

摘要

我们合成了一种新的肿瘤显像剂，即111铟标记的卟啉（111In-ATN-2）。为了对叙利亚金仓鼠体内可移植的胰腺癌进行成像，我们通过全身放射自显影术研究了注射该显像剂72小时后111In-ATN-2的生物分布。将该显像剂的效果与柠檬酸镓的效果进行了比较。结果发现，111In-ATN-2的图像比柠檬酸镓的图像更清晰。前者的肿瘤与组织放射性分布比高于后者。因此，111In-ATN-2似乎对肿瘤诊断更有用。

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Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.血卟啉衍生物与激光光辐射治疗肺癌

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3

Electrophysiological studies on the cultured cells obtained from transplantable pancreatic carcinoma in Syrian golden hamsters.对从叙利亚金黄地鼠可移植性胰腺癌中获取的培养细胞进行的电生理研究。

Peptides. 1984 Mar-Apr;5(2):423-8. doi: 10.1016/0196-9781(84)90247-x.

4

The concentration in tumor and other tissues of parenterally administered tritium- and 14-C-labeled tetraphenylporphinesulfonate.经肠胃外给予的氚和14C标记的四苯基卟啉磺酸盐在肿瘤及其他组织中的浓度。

Cancer Res. 1967 Nov;27(11):2060-4.

5

[Basic study for cancer therapy with porphyrin derivatives and pheophorbide derivatives].[卟啉衍生物和脱镁叶绿酸衍生物用于癌症治疗的基础研究]

Hokkaido Igaku Zasshi. 1985 May;60(3):391-403.

6

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