Ohmiya T
Jpn J Surg. 1983 Mar;13(2):152-8. doi: 10.1007/BF02469537.
Adrenal medullary secretion of dopamine (DA) was investigated during acute hemorrhagic and endotoxin-induced shock in mongrel dogs. Blood samples were collected directly from the adrenal vein and DA content was measured using gas-liquid chromatography equipped with an electron-capture detector (GLC-ECD). The adrenal medullary secretion of DA increased markedly during hemorrhagic and endotoxin-induced shock. In the former, the rate of secretion of DA increased from 0.22 ng/kg/min to 10.7 ng/kg/min in 90 min. After blood transfusion, the rate of secretion of DA decreased rapidly. In the case of endotoxin-induced shock, the rate of secretion of DA increased from 0.20 ng/kg/min to 9.6 ng/kg/min in 120 min. In the cervical spinal transected dogs, the rate of secretion of DA did not increase during hemorrhagic shock. Thus, secretion of DA from the adrenal medulla seems to be primarily controlled by the central nervous system, through the baroreceptor reflex.
研究了杂种狗在急性出血性休克和内毒素性休克期间肾上腺髓质多巴胺（DA）的分泌情况。直接从肾上腺静脉采集血样，使用配备电子捕获检测器的气液色谱法（GLC-ECD）测量DA含量。在出血性休克和内毒素性休克期间，肾上腺髓质DA的分泌显著增加。在前者中，90分钟内DA的分泌速率从0.22纳克/千克/分钟增加到10.7纳克/千克/分钟。输血后，DA的分泌速率迅速下降。在内毒素性休克的情况下，120分钟内DA的分泌速率从0.20纳克/千克/分钟增加到9.6纳克/千克/分钟。在颈髓横断的狗中，出血性休克期间DA的分泌速率没有增加。因此，肾上腺髓质DA的分泌似乎主要受中枢神经系统通过压力感受器反射的控制。
