苯环己哌啶对恒河猴视觉诱发电位的影响。

The effects of phencyclidine on visually evoked potentials of rhesus monkeys.

作者信息

Shelburne S A, McLaurin R L

出版信息

Electroencephalogr Clin Neurophysiol. 1977 Jul;43(1):95-8. doi: 10.1016/0013-4694(77)90199-7.

Abstract

Phenyclidine (Sernylan) was given intramuscularly to 12 rhesus monkeys and electroencephalograms and visually evoked potentials to photic stimulation were recorded. Phencyclidine has profound effects upon VEP's, particularly a marked enhancement of positive components maximal around 100 msec after stimulus presentation. Most likely these effects are related to the level of surgical anesthesia, Stage III, phase I. A correlation was suggested between the increased amplitude of VEP's and the psychotic clinical manifestations of visual perceptual distortions. Physicians and investigators should be aware of the striking effects of this compound, now widely used as a street drug "angel's mist" of "angel's dust", on neurophysiological functions.

摘要

将苯环己哌啶（赛尼兰）肌肉注射给12只恒河猴，并记录脑电图以及光刺激诱发的视觉诱发电位。苯环己哌啶对视觉诱发电位有深远影响，尤其是刺激呈现后约100毫秒时阳性成分显著增强。这些影响很可能与外科麻醉III期I阶段的水平有关。视觉诱发电位振幅增加与视觉感知扭曲的精神病临床表现之间存在关联。医生和研究人员应意识到这种化合物如今作为街头毒品“天使迷雾”或“天使粉”被广泛使用，对神经生理功能有显著影响。