Tachmes L, Fernandez R J, Sackner M A
Chest. 1978 Sep;74(3):243-6. doi: 10.1378/chest.74.3.243.
We studied the hemodynamic effects of smoking cigarettes with high and low contents of nicotine in young smokers free of coronary arterial disease. The smoking of one cigarette with a high content of nicotine produced a peak rise in cardiac output of 32 percent above baseline values, and the effect persisted for one hour. Smoking a cigarette with a low content of nicotine produced a peak rise of 13 percent above baseline values, with a duration of five minutes. The rise in cardiac output was almost entirely attributable to tachycardia, since stroke volume remained relatively constant. The smoking of a cigarette with high nicotine content also caused greater and more sustained elevation in systemic blood pressure than smoking a cigarette with low nicotine content. Thus, there was a responsiveness to the dose of nicotine in cigarettes smoked by young smokers free of coronary arterial disease.
我们研究了在无冠状动脉疾病的年轻吸烟者中，吸食高尼古丁含量和低尼古丁含量香烟的血流动力学效应。吸食一支高尼古丁含量的香烟会使心输出量峰值比基线值升高32%，且该效应持续一小时。吸食一支低尼古丁含量的香烟会使心输出量峰值比基线值升高13%，持续五分钟。心输出量的增加几乎完全归因于心动过速，因为每搏输出量保持相对恒定。与吸食低尼古丁含量的香烟相比，吸食高尼古丁含量的香烟还会导致全身血压升高幅度更大且持续时间更长。因此，无冠状动脉疾病的年轻吸烟者对所吸香烟中的尼古丁剂量存在反应性。
