Serrano J S, Hernández J, Miñaño J
Methods Find Exp Clin Pharmacol. 1983;5(4):251-4.
The effects of GABA, its quaternary derivative N-trimethyl GABA and quinidine have been studied in a model of ventricular automaticity induced in the isolated right ventricle of the rat. GABA shows low anti-automatic activity. N-trimethyl GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacy of the latter two drugs at 5 X 10(-5) M was not significantly different. We conclude that N-trimethyl GABA has some anti-automatic activity in this experimental model, similar to a classic antidysrhythmic drug such as quinidine, that would warrant further research.
在大鼠离体右心室诱发的心室自律性模型中，研究了γ-氨基丁酸（GABA）、其季铵衍生物N-三甲基GABA和奎尼丁的作用。GABA显示出较低的抗自律活性。然而，N-三甲基GABA和奎尼丁是降低心室自律性的非常有效的药物。后两种药物在5×10⁻⁵M浓度时的疗效无显著差异。我们得出结论，在该实验模型中，N-三甲基GABA具有一定的抗自律活性，类似于奎尼丁等经典抗心律失常药物，这值得进一步研究。
