Painter T D
Postgrad Med. 1983 Sep;74(3):341-5, 348, 350. doi: 10.1080/00325481.1983.11698439.
Anticoagulant therapy is required for a variety of indications. Heparin, usually administered intravenously, is the drug of choice for acute anticoagulation, with the infusion monitored by partial thromboplastin time. For long-term therapy the standard regimen includes heparin given via intravenous infusion for 7 to 14 days followed by oral warfarin therapy, monitored by prothrombin time. The duration of anticoagulant therapy depends on the indication for its use. The most serious complication with the anticoagulants is bleeding. Physicians should be aware of the risk factors for bleeding and of the measures capable of reversing the effects of the drugs.
抗凝治疗适用于多种适应症。肝素通常通过静脉给药，是急性抗凝治疗的首选药物，通过部分凝血活酶时间监测输注情况。对于长期治疗，标准方案包括静脉输注肝素7至14天，随后进行口服华法林治疗，并通过凝血酶原时间进行监测。抗凝治疗的持续时间取决于使用指征。抗凝剂最严重的并发症是出血。医生应了解出血的危险因素以及能够逆转药物作用的措施。
