Tang A H, Franklin S R
Pharmacol Biochem Behav. 1983 Jun;18(6):873-7. doi: 10.1016/s0091-3057(83)80008-2.
The acquisition of shock avoidance behavior by rats was studied in an automated Y-maze which incorporates a simultaneous brightness discrimination paradigm. When administered prior to each of 5 consecutive daily sessions, two opiate derivatives with psychotomimetic properties, cyclazocine and N-allylnormetazocine, impaired the acquisition of brightness discrimination at doses which also increased movements between trials. These effects were similar to those produced by phencyclidine, ketamine, and a high dose of d-amphetamine. Pretreatment with morphine, pentazocine and scopolamine at motor stimulant doses before each training session did not affect acquisition of brightness discrimination. Nalorphine, naltrexone, and chlorpromazine also had no effect on brightness discrimination, even at motor depressant doses. Whereas the motor stimulation produced by morphine or pentazocine was blocked by naltrexone, the motor stimulation and discrimination disruption produced by cyclazocine or N-allylnormetazocine were only incompletely antagonized by naltrexone. The results demonstrate similarities between psychotomimetic opiates and phencyclidine-like compounds and may reflect the sensory or cognitive disturbance produced by these drugs in man.
在一个采用同时亮度辨别范式的自动Y型迷宫中，对大鼠习得回避电击行为进行了研究。在连续5天每天的实验前给药时，两种具有拟精神病特性的阿片衍生物——环唑辛和N -烯丙基去甲左啡诺，在增加试验间活动量的剂量下，损害了亮度辨别的习得。这些效应与苯环己哌啶、氯胺酮和高剂量的右旋苯丙胺所产生的效应相似。在每次训练前以运动兴奋剂剂量给予吗啡、喷他佐辛和东莨菪碱，并不影响亮度辨别的习得。纳洛啡、纳曲酮和氯丙嗪即使在运动抑制剂剂量下，对亮度辨别也没有影响。虽然纳曲酮可阻断吗啡或喷他佐辛产生的运动兴奋，但纳曲酮只能不完全拮抗环唑辛或N -烯丙基去甲左啡诺产生的运动兴奋和辨别破坏。结果表明拟精神病性阿片类药物和苯环己哌啶样化合物之间存在相似性，这可能反映了这些药物在人类中产生的感觉或认知障碍。
