Conway E L, Jarrott B
Clin Exp Hypertens A. 1982;4(8):1323-34. doi: 10.3109/10641968209060792.
Clonidine (10 micrograms/kg/hr) was administered continuously to normotensive rats for 5 days using osmotic minipumps. This treatment attenuated the episodic fluctuations in blood pressure normally observed during rapid eye movement (REM) sleep. However, 18-24 hr after withdrawal of clonidine, pronounced fluctuations in blood pressure superimposed upon tonic increases in pressure as well as muscular twitching and irregular respiration were seen during sleep. These responses were abolished by an injection of clonidine or phentolamine. The results demonstrate that after withdrawal of clonidine administration, an increased lability of blood pressure occurs during sleep and probably results from an increased frequency and duration of REM sleep.
使用渗透微型泵对正常血压大鼠连续5天给予可乐定（10微克/千克/小时）。该处理减弱了在快速眼动（REM）睡眠期间通常观察到的血压波动。然而，可乐定撤药后18 - 24小时，睡眠期间出现了叠加在血压持续性升高之上的明显血压波动以及肌肉抽搐和不规则呼吸。注射可乐定或酚妥拉明可消除这些反应。结果表明，可乐定给药撤药后，睡眠期间血压的不稳定性增加，这可能是由于REM睡眠的频率和持续时间增加所致。
