Pal A K, Kabir S N, Pakrashi A
Contraception. 1982 Jun;25(6):639-48. doi: 10.1016/0010-7824(82)90065-8.
Oral administration of aristolic acid (90 mg/kg body weight) on day 6 pregnant and pseudopregnant mice resulted in the termination of pregnancy with in utero fetal death but the length of pseudopregnancy remained unaffected. Peripheral level of progesterone remained statistically uninfluenced in both conditions and exogenous progesterone failed to prevent aristolic acid-induced pregnancy loss, both of which rule out the involvement of luteolysis as the causal factor for the termination of pregnancy. In another experiment, aristolic acid was found to have no inhibitory effect over the maintenance of decidual cell reaction which indicates no inhibitory influence of the compound on uterine utilization of progesterone but points to the fact that presence of concepts is an essential component in the array of mechanism(s) leading to the termination of pregnancy. Probable toxic effect of aristolic acid on the concepts is discussed.
在怀孕第6天和假孕小鼠中口服马兜铃酸（90毫克/千克体重）会导致妊娠终止，子宫内胎儿死亡，但假孕时长不受影响。两种情况下外周孕酮水平在统计学上均未受影响，外源性孕酮也无法预防马兜铃酸诱导的妊娠丢失，这两者都排除了黄体溶解是妊娠终止的因果因素。在另一项实验中，发现马兜铃酸对蜕膜细胞反应的维持没有抑制作用，这表明该化合物对子宫利用孕酮没有抑制作用，但指出一个事实，即胚胎的存在是导致妊娠终止的一系列机制中的一个重要组成部分。文中讨论了马兜铃酸对胚胎可能的毒性作用。
