Kuhn E, Brodan V
Eur J Appl Physiol Occup Physiol. 1982;49(2):215-22. doi: 10.1007/BF02334070.
The effect of 5 days of sleep deprivation on the circadian rhythm of serum iron was studied in a group of six healthy male volunteers. The results were compared with a control group of five individuals, whose normal sleep cycle was preserved, but whose daily regimen was otherwise identical with the sleep deprivation group. Their biorhythm was processed mathematically using cosinor analysis. Sleep deprivation markedly reduced the mean level of iron, diminished the absolute and relative amplitude of oscillations, disturbed the shape of the daily course of serum iron and gradually decreased the computative acrophase, i.e., shortened the period of rhythm. Forty-eight hours of recovery resulted only in a partial normalization of all the observed changes. The potential mechanisms of the observed changes are discussed.
在一组六名健康男性志愿者中研究了五天睡眠剥夺对血清铁昼夜节律的影响。将结果与一个五人对照组进行比较，该对照组保持正常睡眠周期，但其日常作息在其他方面与睡眠剥夺组相同。使用余弦分析对他们的生物节律进行数学处理。睡眠剥夺显著降低了铁的平均水平，减小了振荡的绝对和相对幅度，扰乱了血清铁每日变化过程的形状，并逐渐降低了计算得出的峰相位，即缩短了节律周期。48小时的恢复仅使所有观察到的变化部分恢复正常。讨论了观察到的变化的潜在机制。
