Yamaguchi N, Maeda K, Kuromaru S
Folia Psychiatr Neurol Jpn. 1978;32(4):479-87. doi: 10.1111/j.1440-1819.1978.tb00155.x.
The circadian rhythm of plasma cortisol levels was studied in 20 endogenous depressive patients who received one-night sleep deprivation therapy and 10 normal controls who were also deprived of sleep together with patients by estimation at four-hourly intervals over 36 hours. The mean values at each sampling time were compared. The result can be summarized as follows: The mean values of depressive patients tended to be higher than those of controls on the day following sleep deprivation. In depressive patients the mean values on the following day were higher compared to those on the preceding day. In the patients who responded well to sleep deprivation therapy, the circadian variation of mean values which was obscure the preceding day showed an evident rhythm the following day. These findings suggest that sleep deprivation may cause a different effect between depressive patients and normal subjects, and that the possible mechanism of the anti-depressive efficacy of sleep deprivation may be to normalize the disturbed rhythm of the physiological function in depressive patients.
对20例接受一晚睡眠剥夺疗法的内源性抑郁症患者以及10名与患者一同被剥夺睡眠的正常对照者，每隔4小时进行一次评估，持续36小时，研究了血浆皮质醇水平的昼夜节律。比较了每个采样时间的平均值。结果总结如下：睡眠剥夺后的第二天，抑郁症患者的平均值往往高于对照组。抑郁症患者第二天的平均值高于前一天。在对睡眠剥夺疗法反应良好的患者中，前一天不明显的平均值昼夜变化在第二天表现出明显的节律。这些发现表明，睡眠剥夺可能对抑郁症患者和正常受试者产生不同的影响，睡眠剥夺抗抑郁疗效的可能机制可能是使抑郁症患者生理功能紊乱的节律恢复正常。
