Csiza C K
J Lipid Res. 1982 Jul;23(5):720-5.
Brains and spinal cords of myelin-deficient (md) and littermate control rats were analyzed serially for myelin lipids during the period from 13 to 32 days of age. The glycolipids of md rat brains were severely reduced and remained so during the period of study; brain cholesterol and phospholipids increased moderately but never reached the values for control brains. Deficiency of all three lipid classes was marked in the spinal cord and did not change with age. Among the glycolipids of md rats, deficiency was more severe in cerebrosides than sulfatides. The pronounced reduction of cerebrosides in the early stages of myelination suggests that abnormal synthesis of these glycolipids may be the most important biochemical anomaly responsible for myelin deficiency.--Csiza, C.K. Lipid class analysis of the central nervous system of myelin-deficient Wistar rats.
在13至32日龄期间，对髓磷脂缺乏（md）大鼠及其同窝对照大鼠的脑和脊髓进行了连续的髓磷脂脂质分析。md大鼠脑内的糖脂严重减少，在研究期间一直如此；脑胆固醇和磷脂适度增加，但从未达到对照脑的值。脊髓中所有三类脂质均明显缺乏，且不随年龄变化。在md大鼠的糖脂中，脑苷脂的缺乏比硫脂更严重。髓鞘形成早期脑苷脂的显著减少表明，这些糖脂的异常合成可能是导致髓磷脂缺乏的最重要的生化异常。——齐扎，C.K. 髓磷脂缺乏的Wistar大鼠中枢神经系统的脂质类分析
