Lomas D E, Keverne E B
J Reprod Fertil. 1982 Sep;66(1):101-7. doi: 10.1530/jrf.0.0660101.
Young female mice were grouped on Day 21 after birth and subjected to removal of the vomeronasal organ. Soiled bedding from intact adult males failed to advance the onset of first oestrus in these lesioned mice compared to the various control groups. Vomeronasal organ lesions of prepubertal females also prevented increases in uterine weight following exposure to soiled bedding for 48 h on Day 23 when compared to controls. Lowering prolactin by injections of bromocriptine for 48 h on Day 26, but not Day 23, advanced the onset of puberty in intact and vomeronasal organ-lesioned females. Elevating prolactin by injections of domperidone were without effect on the early onset of oestrus when compared to sham-injected controls. It is concluded that marked similarities exist in both the receptor system and neuroendocrine mechanism of male pheromone action observed in prepubertal females and that seen in the adult.
出生后第21天，将幼年雌性小鼠分组并摘除犁鼻器。与各个对照组相比，来自完整成年雄性小鼠的脏垫料未能使这些受损小鼠的首次发情期提前。与对照组相比，青春期前雌性小鼠的犁鼻器损伤也阻止了在第23天接触脏垫料48小时后子宫重量的增加。在第26天而非第23天注射溴隐亭48小时降低催乳素水平，可使完整和犁鼻器受损的雌性小鼠青春期提前。与假注射对照组相比，注射多潘立酮提高催乳素水平对发情期提前没有影响。结论是，青春期前雌性小鼠中观察到的雄性信息素作用的受体系统和神经内分泌机制与成年小鼠中观察到的存在明显相似之处。
