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向大鼠纹状体双侧注射海藻酸可增强吗啡、槟榔碱和毛果芸香碱的作用,但不增强氟哌啶醇致僵作用。

Bilateral injection of kainic acid into the rat striatum potentiates morphine, arecoline and pilocarpine but not haloperidol catalepsy.

作者信息

Turski W, Czuczwar S J, Turski L, Kleinrok Z

出版信息

Methods Find Exp Clin Pharmacol. 1982;4(5):287-91.

PMID:6889661
Abstract

Bilateral injections of 3 nmol of kainic acid into the rat caudate nucleus potentiated morphine, arecoline and pilocarpine catalepsy but attenuated the cataleptic response to haloperidol. These results confirm the primary importance of caudate nucleus in the appearance of neuroleptic catalepsy and suggest that this nucleus plays an important role in the inhibitory control of cataleptic responses to narcotics and cholinomimetics.

摘要

向大鼠尾状核双侧注射3纳摩尔的 kainic 酸可增强吗啡、槟榔碱和毛果芸香碱引起的僵住症,但减弱对氟哌啶醇的僵住症反应。这些结果证实了尾状核在抗精神病药物所致僵住症出现中的首要重要性,并表明该核在对麻醉药和拟胆碱药的僵住症反应的抑制控制中起重要作用。

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