Husslein P, Fuchs A R, Fuchs F
Z Geburtshilfe Perinatol. 1982 Jun-Jul;186(3):141-4.
In order to test the hypothesis that oxytocin not only leads to myometrial contractions but also to an increase of prostaglandin synthesis in decidua, human decidua, myometrium and amnion were incubated with and without oxytocin in a modified Krebs-bicarbonate-solution. The addition of oxytocin led to a significant increase of PG E- and PG F-synthesis in decidua and to a significant increase in PG-synthesis in amnion. In 15 women in whom labor was induced by intravenous infusion of oxytocin PGFM concentrations were measured before and during induction. PGFM levels rose in all women in whom induction was successful, whereas they stayed unchanged in those women in whom induction failed. These results support the hypothesis that oxytocin leads to an increase in prostaglandin production through specific receptors in decidua.
为了验证催产素不仅能引起子宫肌层收缩，还能增加蜕膜中前列腺素合成这一假说，将人蜕膜、子宫肌层和羊膜在改良的 Krebs - 碳酸氢盐溶液中分别在有和没有催产素的情况下进行孵育。添加催产素导致蜕膜中前列腺素 E 和前列腺素 F 的合成显著增加，羊膜中前列腺素的合成也显著增加。在 15 名通过静脉输注催产素引产的妇女中，在引产前后测量了 PGFM 浓度。在所有引产成功的妇女中，PGFM 水平升高，而在引产失败的妇女中，PGFM 水平保持不变。这些结果支持了催产素通过蜕膜中的特定受体导致前列腺素产生增加这一假说。
