单剂量双孢蘑菇的4-（羟甲基）苯重氮离子诱导胃肿瘤发生
Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus.
作者信息
Toth B, Nagel D, Ross A
出版信息
Br J Cancer. 1982 Sep;46(3):417-22. doi: 10.1038/bjc.1982.218.
Abstract
4-(Hydroxymethyl-benzenediazonium tetrafluoroborate was administered as a single intragastric instillation at 400 micrograms/g to Swiss albino mice. The treatment gave rise to glandular stomach tumours in incidences of 30% in females and 32% in males. Histopathologically, the tumours were classified as polypoid adenomas and adenocarcinomas. This diazonium ion is an ingredient of the cultivated mushroom of commerce, Agaricus bisporus. The implications are self-evident.
摘要
将4-（羟甲基）苯重氮四氟硼酸盐以400微克/克的剂量单次灌胃给予瑞士白化小鼠。该处理导致雌性小鼠腺胃肿瘤发生率为30%，雄性小鼠为32%。组织病理学上，肿瘤被分类为息肉状腺瘤和腺癌。这种重氮离子是商业栽培蘑菇双孢蘑菇的一种成分。其影响不言而喻。
Zotero 插件