Czarnecki W, Herbaczynska-Cedro K
Clin Physiol. 1982 Jun;2(3):189-97. doi: 10.1111/j.1475-097x.1982.tb00023.x.
In acute experiments on open chest pigs 15 min occlusions of the left anterior descending coronary artery were performed, each occlusion followed by 45 min reperfusion. Myocardial ischaemia was defined by epicardial electrogram recorded from the border of the ischaemic area. Myocardial extraction of lactate and glucose as well as the extraction of FFA were measured before and at the 15th min of occlusion. Inosine (5 mg/kg/min) or 0.9% NaCl infusion was administered i.v. throughout the occlusion period. Inosine significantly diminished the number of ischaemic points and reduced an increase in R-wave voltage induced by coronary occlusion. Myocardial extraction of measured substrates was not significantly influenced by inosine administration. In conclusion, inosine decreases the area of ischaemic injury induced by acute coronary occlusion in the pig.
在对开胸猪进行的急性实验中，对左前降支冠状动脉进行了15分钟的闭塞，每次闭塞后再灌注45分钟。心肌缺血通过从缺血区域边界记录的心外膜电图来定义。在闭塞前和闭塞第15分钟时测量心肌对乳酸、葡萄糖以及游离脂肪酸（FFA）的摄取。在整个闭塞期间静脉内输注肌苷（5mg/kg/分钟）或0.9%氯化钠。肌苷显著减少了缺血点的数量，并降低了冠状动脉闭塞引起的R波电压升高。给予肌苷对所测底物的心肌摄取没有显著影响。总之，肌苷可减少猪急性冠状动脉闭塞诱导的缺血损伤面积。
