Woollard K V, Kingaby R O, Lab M J, Cole A W, Palmer T N
Cardiovasc Res. 1981 Nov;15(11):659-67. doi: 10.1093/cvr/15.11.659.
Intravenous infusion of inosine (15 mg.kg-1.min-1) to the open-chested pig resulted in hypotension, coronary vasodilatation and slightly increased myocardial contractility. Following coronary occlusion, the action of inosine to increase myocardial contractility was apparently selective. Regional myocardial performance of ischaemic myocardium was increased significantly relative to nonischaemic. The selectivity of inotropic action was not mimicked by glucose-insulin-potassium. It is concluded that the selectivity is multifactoral and that the inotropic, vasodilatory and metabolic actions of the nucleoside contribute to the apparent selectivity.
给开胸猪静脉输注肌苷（15毫克·千克⁻¹·分钟⁻¹）会导致低血压、冠状动脉扩张以及心肌收缩力略有增加。冠状动脉闭塞后，肌苷增加心肌收缩力的作用明显具有选择性。缺血心肌的局部心肌功能相对于非缺血心肌显著增强。葡萄糖 - 胰岛素 - 钾并未模拟出这种变力作用的选择性。得出的结论是，这种选择性是多因素的，并且该核苷的变力、血管舒张和代谢作用促成了这种明显的选择性。
