年龄会改变多巴胺能系统对雌二醇的反应。
Age alters dopaminergic responses to estradiol.
作者信息
Roy E J, Sheinkop S, Wilson M A
出版信息
Eur J Pharmacol. 1982 Aug 13;82(1-2):73-5. doi: 10.1016/0014-2999(82)90554-4.
PMID:6889971
Abstract
Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [3H]spiroperidol by striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.
摘要
对年轻（3 - 5个月）和中年（17 - 19个月）去卵巢大鼠用苯甲酸雌二醇治疗三天，并通过行为学（对阿扑吗啡的转圈反应）和神经化学方法（纹状体膜对[3H]螺哌啶醇的结合）评估纹状体多巴胺能功能。结果表明，与年轻动物相比，老年动物的纹状体多巴胺能功能对雌激素的反应可能不同。
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