Hruska R E, Ludmer L M, Pitman K T, De Ryck M, Silbergeld E K
Pharmacol Biochem Behav. 1982 Feb;16(2):285-91. doi: 10.1016/0091-3057(82)90162-9.
The present study compares, biochemically and behaviorally, the effect of estrogen on central dopamine (DA) function in male and female rats. Estrogen has no direct effect in vitro on DA receptors from striatal tissue of male or female rats. In vivo administration of 17 beta-estradiol valerate to male or long-term ovariectomized female rats significantly increased the density of the striatal Da receptors by about 20 percent. Behaviorally, normal female rats have more intense stereotypy produced by apomorphine (APO stereotypy), regardless of the phase of their estrous cycle, than normal male rats, while the density of striatal DA receptors is equal. Estrogen administration to male rats increases their APO stereotypy. Normal intact female rats have no changes in APO stereotypy after the administration of estrogen. However, ovariectomy of female rats increases APO stereotypy, and estrogen administration decreases APO stereotypy back to the levels observed in the normal intact female rats. In the male rat there is a good correlation between the increased striatal Da receptor density and the increased APO stereotypy, but in the female rat factors other than striatal DA receptor density density appear to be important in the regulation of APO stereotypy.
本研究从生化和行为学方面比较了雌激素对雄性和雌性大鼠中枢多巴胺（DA）功能的影响。雌激素在体外对雄性或雌性大鼠纹状体组织的DA受体没有直接作用。给雄性或长期卵巢切除的雌性大鼠体内注射戊酸雌二醇17β，可使纹状体DA受体密度显著增加约20%。在行为学方面，无论处于发情周期的哪个阶段，正常雌性大鼠由阿扑吗啡引起的刻板行为（APO刻板行为）都比正常雄性大鼠更强烈，而纹状体DA受体密度是相等的。给雄性大鼠注射雌激素会增加其APO刻板行为。正常未切除卵巢的雌性大鼠注射雌激素后APO刻板行为没有变化。然而，雌性大鼠卵巢切除会增加APO刻板行为，而注射雌激素会使APO刻板行为降低至正常未切除卵巢雌性大鼠所观察到的水平。在雄性大鼠中，纹状体DA受体密度增加与APO刻板行为增加之间存在良好的相关性，但在雌性大鼠中，除纹状体DA受体密度外的其他因素似乎在APO刻板行为的调节中起重要作用。
