Sassenrath E N, Jensen G D, Blanton F L
Neurobiol Aging. 1982 Summer;3(2):111-6. doi: 10.1016/0197-4580(82)90005-7.
Cycling older premenopausal female bonnet macaques (17 to 18 years) show decreased attractivity (mounting indices) and responsivity to males in short-term pair-testing compared to younger, fully mature cycling females (9 to 13 years). Comparison of age-group mean circulating levels of estrogen, progesterone, and testosterone during four phases of the menstrual cycle shows a significant decrement in older females only in the height of the estrogen surge during the periovulatory (estrous) phase of the cycle. Supplementation of older females with an estradiol + testosterone preparation (Deladumone, Squibb) did not restore behavioral sexual interaction to the level of younger females. The data suggest a gradual decline in sexual responsivity or arousal in older females which precedes the major endocrine changes of menopause. Such a lowering of responsivity appears comparable to that observed in aging (albeit sexually functional) human males.
与年轻的、完全成熟的处于发情期的雌性猕猴（9至13岁）相比，年龄较大的绝经前雌性猕猴（17至18岁）在短期配对测试中对雄性的吸引力（骑跨指数）和反应性降低。比较月经周期四个阶段中不同年龄组雌激素、孕酮和睾酮的平均循环水平，发现仅在周期的排卵期（发情期）雌激素激增的高峰期，老年雌性猕猴的这些激素水平显著下降。用雌二醇+睾酮制剂（Deladumone，施贵宝公司）对老年雌性猕猴进行补充，并未使性行为互动恢复到年轻雌性猕猴的水平。数据表明，老年雌性猕猴的性反应或性唤起在绝经的主要内分泌变化之前就逐渐下降。这种反应性的降低似乎与衰老的（尽管仍有性功能）人类男性中观察到的情况相当。
