Zumpe D, Bonsall R W, Michael R P
Behav Neurosci. 1983 Aug;97(4):615-23. doi: 10.1037//0735-7044.97.4.615.
Sixteen ovariectomized rhesus monkeys were paired, each with two males, during thirty-two 28-day periods during which they received one or more of the following schedules of daily injections: (a) different mixtures of estradiol benzoate, progesterone, and testosterone propionate (artificial menstrual cycles), (b) the doses of estradiol benzoate given in artificial cycles but without the other hormones (cyclic estradiol regimens), and (c) appropriate control treatments (625 one-hour behavioral tests). Hormone doses were adjusted to give plasma levels in the physiological range (335 blood samples). Measures of male sexual activity during artificial cycles and during cyclic estradiol regimens showed significant cyclic changes, but these changes were indistinguishable from each other. In four females studied in an operant conditioning paradigm, there was a midcycle dip in the times taken to obtain access to males during the cyclic estradiol regimens. The data indicated that the estrogen state of the female plays a preponderant role in determining the cyclic changes in the behavioral interactions of the pair independently of the effects of other ovarian hormones.
16只去卵巢的恒河猴被配对，每只与两只雄性猴子配对，在32个为期28天的时间段内，它们接受以下一种或多种每日注射方案：(a)苯甲酸雌二醇、孕酮和丙酸睾酮的不同混合物（人工月经周期），(b)人工周期中给予的苯甲酸雌二醇剂量，但不含其他激素（周期性雌二醇方案），以及(c)适当的对照处理（625次一小时行为测试）。调整激素剂量以使血浆水平处于生理范围内（335份血样）。在人工周期和周期性雌二醇方案期间对雄性性活动的测量显示出显著的周期性变化，但这些变化彼此无法区分。在以操作性条件反射范式研究的4只雌性猴子中，在周期性雌二醇方案期间，获得接近雄性猴子机会所需的时间在周期中期出现下降。数据表明，雌性猴子的雌激素状态在决定配对行为相互作用的周期性变化中起主要作用，而与其他卵巢激素的作用无关。
