吗啡及吗啡样药物对卡巴胆碱诱发猫打架行为的影响。
Effect of morphine and morphine-like drugs on carbachol-induced fighting in cats.
作者信息
Krstić S K, Stefanović-Denić K, Beleslin D B
出版信息
Pharmacol Biochem Behav. 1982 Aug;17(2):371-3. doi: 10.1016/0091-3057(82)90095-8.
PMID:6890210
Abstract
In the present experiments, morphine, methadone or pethidine was injected into the cerebral ventricle of the unanesthetized cat after fighting was induced with carbachol injected previously. The fighting evoked by carbachol was sensitive to the depressant action of morphine or pethidine but not to the depressant effect of methadone. The most likely explanation of the depressant effects of the former compounds is that they act on the postsynaptic receptors of central cholinergic neurons.
摘要
在目前的实验中，在用先前注射的卡巴胆碱诱发争斗后，将吗啡、美沙酮或哌替啶注入未麻醉猫的脑室。卡巴胆碱诱发的争斗对吗啡或哌替啶的抑制作用敏感，但对美沙酮的抑制作用不敏感。前一种化合物产生抑制作用最可能的解释是它们作用于中枢胆碱能神经元的突触后受体。
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