Phillips B J, James T E, Gangolli S D
Mutat Res. 1982 Oct-Nov;102(3):297-304. doi: 10.1016/0165-1218(82)90139-2.
The widely used plasticizer di(2-ethylhexyl)phthalate (DEHP), its hydrolysis products mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol, and also phthalic acid have been tested for clastogenic activity in cultured Chinese hamster ovary (CHO) cells. Only MEHP was found to cause chromosome damage. MEHP was without effect in the SCE and HGPRT mutation test in CHO cells. The clastogenicity of MEHP suggests a role for this compound in the observed carcinogenicity of DEHP and its positive effect in the dominant lethal assay.
广泛使用的增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）、其水解产物邻苯二甲酸单（2-乙基己基）酯（MEHP）和2-乙基己醇以及邻苯二甲酸已在培养的中国仓鼠卵巢（CHO）细胞中进行了致断裂活性测试。仅发现MEHP会导致染色体损伤。MEHP在CHO细胞的姐妹染色单体交换（SCE）和次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）突变试验中无作用。MEHP的致断裂性表明该化合物在观察到的DEHP致癌性中起作用，并且在显性致死试验中有阳性效应。
