Becker H, Zaunschirm A, Muntean W, Domej W
Wien Klin Wochenschr. 1982 Jul 9;94(14):364-5.
This paper presents the case report of a 2 year-old boy in whom a grade II fetal alcohol syndrome was diagnosed at 17 months. At 21 months, an embryonal rhabdomyosarcoma of the urinary bladder trigone was found, and the tumour excised. Polychemotherapy was initiated, but bone-marrow depression and death in septicaemic shock followed. The main autopsy findings included the demonstration of tumour remnants in the urinary bladder and prostate, and a severe acute purulent pyelonephritis. This is the fifth case of fetal alcohol syndrome in conjunction with a malignant tumour to be reported in the international literature. These cases do not show any uniformity as to tumour type. No conclusion can as yet be drawn as to whether there is a pathogenetic connection between the fetal alcohol syndrome and the occurrence of malignant tumours (as is the case with the fetal hydantoin syndrome and neuroblastoma), or whether these findings are purely coincidental. Clinicians and pathologists should, however, be advised to look more closely for even minimally pronounced forms of the fetal alcohol syndrome in children with embryonic tumours.
本文报告了一名2岁男孩的病例，该男孩在17个月大时被诊断为二级胎儿酒精综合征。21个月大时，发现膀胱三角区胚胎性横纹肌肉瘤，并切除了肿瘤。开始进行多药化疗，但随后出现骨髓抑制并死于败血症性休克。主要尸检结果包括在膀胱和前列腺中发现肿瘤残余，以及严重的急性化脓性肾盂肾炎。这是国际文献中报道的第五例胎儿酒精综合征合并恶性肿瘤的病例。这些病例在肿瘤类型上没有任何一致性。关于胎儿酒精综合征与恶性肿瘤的发生之间是否存在致病联系（如胎儿苯妥英综合征与神经母细胞瘤的情况），或者这些发现是否纯属巧合，目前尚无定论。然而，应建议临床医生和病理学家更密切地观察患有胚胎性肿瘤的儿童中即使是最轻微的胎儿酒精综合征表现形式。
