Hild P, Aigner K, Henneking K
Anticancer Res. 1982 Jul-Aug;2(4):255-6.
The Cis-platinum levels in isolated extremity perfusion were measured in dogs and man. We found that prolonged presence of Cis-platinum in the tissue is attributed to its strong and rapid binding to serum and tissue proteins. Protein binding follows the concentration gradient. Subsequent re-diffusion into the blood followed by urinary excretion was also noted.
在狗和人类中测量了孤立肢体灌注中顺铂的水平。我们发现，顺铂在组织中的长时间存在归因于它与血清和组织蛋白的强烈且快速结合。蛋白结合遵循浓度梯度。随后还观察到其重新扩散到血液中，然后经尿液排泄。
