Bashour T, Kabbani S, Saalouke M, Sandouk A, Cheng T O
Clin Cardiol. 1982 Oct;5(10):538-43. doi: 10.1002/clc.4960051006.
A 19-year-old male was found to have combined supravalvular aortic stenosis and hypertrophic subaortic stenosis. Two possible hypotheses with supportive evidence in the literature may explain this association: (1) long-standing fixed supravalvular aortic stenosis may result in secondary hypertrophic subaortic stenosis, and (2) infantile hypercalcemia, a condition closely related to supravalvular aortic stenosis, may also be involved by continuous inotropic stimulation in the pathogenesis of muscular hypertrophy and subaortic stenosis of the left ventricle. We tend to favor the second theory in light of recent evidence in the literature.
一名19岁男性被发现患有瓣上主动脉狭窄合并肥厚性主动脉瓣下狭窄。文献中有支持证据的两种可能假说可以解释这种关联：（1）长期存在的固定性瓣上主动脉狭窄可能导致继发性肥厚性主动脉瓣下狭窄；（2）与瓣上主动脉狭窄密切相关的婴儿高钙血症，在左心室肌肉肥厚和主动脉瓣下狭窄的发病机制中，可能也受到持续的变力刺激影响。鉴于文献中的最新证据，我们倾向于支持第二种理论。
