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巨噬细胞在体内对丝状线虫(Setaria setaria)的损伤作用

Macrophage-mediated damage to filarial worms (Dipetalonema setariosum) in vivo.

作者信息

Worms M J, McLaren D J

出版信息

J Helminthol. 1982 Sep;56(3):235-41. doi: 10.1017/s0022149x00034593.

DOI:10.1017/s0022149x00034593
PMID:6890964
Abstract

An adult female Dipetalonema setariosum (Mönnig 1926) recovered from the pleural cavity of Meriones libycus and bearing an adherent cell mass examined by means of electron microscopy. The host reaction consisted exclusively of macrophages and was associated with disruption of the cuticular membrane and invasion of the cuticle itself. There was no evidence of prior activity by other cell types. Initiation of damage appeared to be associated with the release of lysosomal enzymes by the macrophages. Within the reaction a localized breaching of the cuticle had occurred and cells had penetrated the internal tissues of the worm. It is suggested that macrophages may play a role in the elimination of effect worms from an established population.

摘要

从利比亚沙鼠胸膜腔中取出的一只成年雌性塞氏双瓣线虫(Mönnig,1926年),带有一个附着的细胞团,通过电子显微镜进行了检查。宿主反应仅由巨噬细胞组成,与角质膜的破坏和角质层本身的侵入有关。没有其他细胞类型先前活动的证据。损伤的起始似乎与巨噬细胞释放溶酶体酶有关。在反应过程中,角质层出现了局部破裂,细胞已穿透蠕虫的内部组织。有人提出,巨噬细胞可能在从既定种群中清除受影响的蠕虫方面发挥作用。

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Macrophage-mediated damage to filarial worms (Dipetalonema setariosum) in vivo.巨噬细胞在体内对丝状线虫(Setaria setaria)的损伤作用
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