Kalisnik M, Vraspir-Porenta O, Logonder-Mlinsek M, Zorc-Pleskovic R, Pajer Z, Kham-Lindtner T, Zorc M, Skrk J
Neoplasma. 1982;29(5):517-25.
160 mice of the BALB/C strain of both sexes, aged 3 months, were divided into four equal groups out of which two were regularly irritated by a combination of an optical signal and electrical stroke. After one month of irritation one nonirritated and one irritated group were whole body irradiated with a single dose of 6.65 Gy (1.83 Gy/min), the other two groups were sham irradiated. The mice lived until their spontaneous death or one year after irradiation, respectively, when the rest of the animals were sacrificed. The appearance of malignant tumors was noted. Irradiation shortened the survival time while the irritation had an appeasing, compensatory effect, more expressed in the males than in the females. After irradiation the number and assortment of the tumors increased and the latent period essentially shortened. In the irritated animals the number and assortment of the malignant tumors were reduced and a tendency for lengthening of the latent time period was seen; these differences, however, were not statistically significant. In spite of some differences the response in both sexes to irradiation and irritation or their combination was similar.
选取160只3月龄的BALB/C品系雌雄小鼠，将其平均分为四组，其中两组通过光信号和电刺激联合的方式进行定期刺激。刺激一个月后，对一组未受刺激的小鼠和一组受刺激的小鼠进行单次全身照射，剂量为6.65 Gy（1.83 Gy/分钟），另外两组进行假照射。小鼠分别存活至自然死亡或照射后一年，届时处死其余动物，记录恶性肿瘤的出现情况。照射缩短了存活时间，而刺激具有安抚、补偿作用，在雄性小鼠中比在雌性小鼠中表现得更明显。照射后肿瘤的数量和种类增加，潜伏期基本缩短。在受刺激的动物中，恶性肿瘤的数量和种类减少，并且有潜伏期延长的趋势；然而，这些差异在统计学上并不显著。尽管存在一些差异，但两性对照射、刺激或其联合的反应相似。
