Kalisnik M, Vraspir-Porenta O, Kham-Lindtner T, Logonder-Mlinsek M, Skrk J, Pajntar M
Neoplasma. 1981;28(3):275-9.
In the present experiment irritation consisting of a combination of an optic signal followed by a mild electroshock administered at regular intervals was started in 2 groups of animals at the age of 3 months. At 4 months of age, one of the irritated and one of the nonirritated groups were exposed to whole-body gamma irradiation at 20 daily doses of 0.5 Gy (50 rad(, 1.4 Gy/min (140 rad/min), while the other 2 groups were sham-irradiated. The animals were autopsied and the specimens were microscopically studied for the presence of malignant tumors. Malignant tumors involving particularly the testes and lungs and leukosis were found in 29% of males, whereas in females the tumor incidence with mammary, pulmonary and ovarian involvement and leukosis was 39%. The irradiation decreased the minimum latency time in the irritated males and both female groups. In males, the irritation lowered the cumulative prevalence of malignant tumors, a significant decrease being noted at the age of 15 months. In females, it was increased, with a significant rise observed to occur at the end of the experiment. The opposite effects of irritation on the radiation carcinogenesis in males and females can be attributed to the irradiation-induced specific alterations of the gonads in females and, in part, to a longer survival time observed in the irradiated females.
在本实验中，对两组3月龄动物开始进行刺激，刺激由光信号和定期给予的轻度电击组合而成。4月龄时，将其中一组受刺激动物和一组未受刺激动物每天以20次剂量、每次0.5 Gy（50拉德，1.4 Gy/分钟（140拉德/分钟））进行全身γ射线照射，而另外两组进行假照射。对动物进行尸检，并对标本进行显微镜检查以确定是否存在恶性肿瘤。在雄性动物中，发现29%出现了尤其累及睾丸和肺部的恶性肿瘤以及白血病，而在雌性动物中，出现累及乳腺、肺部和卵巢的肿瘤以及白血病的发生率为39%。照射缩短了受刺激雄性动物和两组雌性动物的最短潜伏期。在雄性动物中，刺激降低了恶性肿瘤的累积发生率，在15月龄时出现显著下降。在雌性动物中，发生率增加，在实验结束时观察到显著上升。刺激对雄性和雌性辐射致癌作用产生相反影响的原因可能是，照射导致雌性动物性腺发生特异性改变，部分原因是照射后的雌性动物存活时间更长。
