Puglisi-Allegra S, Oliverio A, Mandel P
Pharmacol Biochem Behav. 1982 Oct;17(4):691-4. doi: 10.1016/0091-3057(82)90347-1.
Opiate antagonists naloxone (1 and 1.5 mg/kg IP) and naltrexone (2.5 and 5 mg/kg IP) inhibit aggressive responses of DBA/2 isolated mice, while increasing the duration of some social activities such as sniff-body, sniff-nose and following. At the doses employed naloxone and naltrexone did not affect motor activity and self-grooming of paired mice. These findings are discussed in terms of the endogenous opioids system involvement in arousability, in the response of the organism to stressful events, in the motivational mechanisms which control social behavior and in the functioning of some neurotransmitter systems which are known to play an important role in the control of isolation-induced aggressive behavior.
阿片类拮抗剂纳洛酮（腹腔注射剂量为1和1.5毫克/千克）和纳曲酮（腹腔注射剂量为2.5和5毫克/千克）可抑制DBA/2品系隔离小鼠的攻击反应，同时增加诸如嗅身体、嗅鼻子和跟随等一些社交活动的持续时间。在所使用的剂量下，纳洛酮和纳曲酮不影响配对小鼠的运动活动和自我梳理行为。从内源性阿片系统参与觉醒、机体对应激事件的反应、控制社会行为的动机机制以及一些已知在控制隔离诱导的攻击行为中起重要作用的神经递质系统的功能等方面对这些发现进行了讨论。
