Sherlock S
Semin Liver Dis. 1982 Aug;2(3):202-10. doi: 10.1055/s-2008-1040708.
A variety of conditions may lead to the development of portal hypertension in the absence of cirrhosis. In virtually all cases, increased resistance to flow at the level of the portal vein, sinusoids, or hepatic vein is the major contributing factor to the elevated portal pressure, although increased flow may be a contributor in certain instances. Variceal hemorrhage is the major complication of these disorders, but is better tolerated than in cirrhosis because of better hepatocellular function. Therapy should in general be conservative and directed toward any underlying pathology, where such can be identified.
多种情况可导致在无肝硬化的情况下发生门静脉高压。实际上，在所有病例中，门静脉、肝血窦或肝静脉水平的血流阻力增加是门静脉压力升高的主要促成因素，尽管在某些情况下血流增加也可能是一个促成因素。静脉曲张出血是这些疾病的主要并发症，但由于肝细胞功能较好，比肝硬化时更能耐受。一般来说，治疗应采取保守措施，并针对任何可识别的潜在病理情况。
