Stong R C, Houser W D, Stone W H
Vet Immunol Immunopathol. 1982 Nov;3(6):611-27. doi: 10.1016/0165-2427(82)90044-7.
Hemolytic disease of the newborn has not been observed in rhesus monkeys even though the newborn's erythrocytes may be coated with maternal antibodies. Using a 51chromium-erythrocyte survival assay, we found that maternal antibodies do not mediate immune elimination of newborn's red blood cells. However, certain allogeneic or xenogeneic antibodies mediate clearance via sequestration by the reticuloendothelial system, or by intravascular hemolysis, or by a combination of these. The class of antibody plays a major role in elimination since red cells coated with IgG but not with IgM were rapidly cleared. In addition, the quantity of antibody controls the rate and extent of clearance. A comparison of rhesus alloantisera suggests that coating of multiple antigenic sites is necessary for clearance. Passive immunization with selected high-titered anti-erythrocyte alloantisera can induce some hematologic signs of erythrocyte destruction in newborn monkeys.
尽管新生恒河猴的红细胞可能被母体抗体包被，但尚未观察到新生恒河猴发生新生儿溶血病。通过51铬-红细胞存活试验，我们发现母体抗体并不介导对新生儿红细胞的免疫清除。然而，某些同种异体或异种抗体可通过网状内皮系统的隔离、血管内溶血或两者结合来介导清除。抗体的类别在清除过程中起主要作用，因为被IgG而非IgM包被的红细胞会被迅速清除。此外，抗体的量控制着清除的速率和程度。对恒河猴同种抗血清的比较表明，多个抗原位点的包被对于清除是必要的。用选定的高滴度抗红细胞同种抗血清进行被动免疫可在新生猴中诱发一些红细胞破坏的血液学体征。
