Svensson S E, Lomsky M, Olsson L, Persson S, Strauss H W, Westling H
Clin Physiol. 1982 Dec;2(6):467-77. doi: 10.1111/j.1475-097x.1982.tb00053.x.
The distribution of cardiac output, as expressed by the regional uptake of thallium-201 following injection, has been studied by whole body scanning with a gamma-camera in six healthy persons and eight patients with aortic valvular disease. In the patients, cardiac output at rest and during exercise was also measured by the dye dilution technique. Combining the values of cardiac output and regional thallium uptake enabled the calculation of organ blood flow. The myocardial uptake of thallium at rest was 3.2 +/- 0.32% in the control group, which is significantly lower than 8.3 +/- 1.52%, found in the patients. The corresponding values measured in the kidneys were 12.5 +/- 1.91% in the healthy subjects and 7.1 +/- 0.50% in the patient material. Myocardial uptake increased and kidney uptake decreased in both groups following injection at peak exercise. Thallium uptake in the legs increased from about 13% at rest to about 39% at exercise in both groups. Distribution of thallium after injection at peak exercise did not, however, vary significantly between the two groups in the kidneys, abdominal area or the legs. Further methodological work is required before it can be ascertained to what extent the regional thallium uptake reflects the distribution of cardiac output. We nevertheless propose that the technique should be explored further, since it appears to be a simple non-invasive means of visualizing the distribution of the cardiac output in man under certain conditions.
通过γ相机全身扫描，对6名健康人和8名主动脉瓣疾病患者注射201铊后的摄取情况进行了研究，以此来观察心输出量的分布。对于患者，还采用染料稀释技术测量了静息和运动时的心输出量。结合心输出量和局部铊摄取的值，能够计算器官血流量。对照组静息时心肌对铊的摄取为3.2±0.32%，显著低于患者组的8.3±1.52%。健康受试者肾脏的相应测量值为12.5±1.91%，而患者材料中的值为7.1±0.50%。两组在运动高峰注射后，心肌摄取增加，肾脏摄取减少。两组腿部铊摄取量从静息时的约13%增加到运动时的约39%。然而，运动高峰注射后，两组在肾脏、腹部区域或腿部的铊分布没有显著差异。在确定局部铊摄取在多大程度上反映心输出量分布之前，还需要进一步的方法学研究。不过，我们建议进一步探索该技术，因为它似乎是一种在某些情况下可视化人体心输出量分布的简单非侵入性方法。
