Strauss H W, Harrison K, Pitt B
J Nucl Med. 1977 Dec;18(12):1167-70.
Sapirstein (1) employed cationic radiopotassium to determine the fractional distribution of cardiac output to several organs. Thallium-201 can substitute for radiopotassium in myocardial imaging, and was evaluated in the present studies to determine the distribution of cardiac output in the anesthetized dog in comparison with tracer microspheres, both under control circumstances and following the infusion of norepinephrine in a dose sufficient to raise the blood pressure 20 mm Hg above control levels. The concentrations of thallium-201 and microspheres were similar in the heart, kidney, thyroid, and skeletal muscle in both control and norepinephrine-treated animals (r=0.93). Thallium concentration in the liver and lung exceeded that of microspheres, however, and probably is not related solely to the regional distribution of arterial perfusion. These data suggest that in the heart, kidney, thyroid, and skeletal muscle, thallium-201 distribution reflects the fractional distribution of cardiac output.
萨皮尔斯坦（1）采用阳离子放射性钾来确定心输出量在几个器官中的分布分数。铊-201可在心肌显像中替代放射性钾，在本研究中对其进行了评估，以确定与示踪微球相比，在麻醉犬中的心输出量分布，包括在对照情况下以及在输注足以使血压比对照水平升高20毫米汞柱的去甲肾上腺素之后。在对照动物和去甲肾上腺素处理的动物中，心脏、肾脏、甲状腺和骨骼肌中的铊-201和微球浓度相似（r = 0.93）。然而，肝脏和肺中的铊浓度超过了微球的浓度，并且可能不仅仅与动脉灌注的区域分布有关。这些数据表明，在心脏、肾脏、甲状腺和骨骼肌中，铊-201的分布反映了心输出量的分布分数。
