避免乙醇和偏好乙醇的C57BL小鼠的全脑甲硫氨酸脑啡肽
Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL mice.
作者信息
Blum K, Briggs A H, DeLallo L, Elston S F, Ochoa R
出版信息
Experientia. 1982 Dec 15;38(12):1469-70. doi: 10.1007/BF01955775.
PMID:6891340
Abstract
These experiments systematically investigated ethanol preference in both the C57Bl/6N and C57Bl/6J mice utilizing three-choice 2-bottle preference test. In addition, these sublines were evaluated for whole brain methionine-enkephalin levels, which were significantly lower in C57Bl/6J mice (alcohol preferring) compared to C57Bl/6N mice (alcohol non-preferring). This finding supports the involvement of the peptidyl opiates in ethanol seeking behavior.
摘要
这些实验利用三选一的双瓶偏好测试系统地研究了C57Bl/6N和C57Bl/6J小鼠对乙醇的偏好。此外，还评估了这些亚系的全脑甲硫氨酸脑啡肽水平，与C57Bl/6N小鼠（非酒精偏好型）相比，C57Bl/6J小鼠（酒精偏好型）的该水平显著更低。这一发现支持了肽类阿片参与乙醇寻求行为。
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