乙醇接受量作为脑内[甲硫氨酸]脑啡肽基因型数量的函数。
Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin.
作者信息
Blum K, Elston S F, DeLallo L, Briggs A H, Wallace J E
出版信息
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6510-2. doi: 10.1073/pnas.80.21.6510.
Abstract
Our results indicate a negative correlation between the amount of ethanol (10%) consumed and endogenous levels of brain [Met]enkephalin in C57BL/6J (alcohol-preferring) and DBA/2J (alcohol-nonpreferring) inbred mice strains. Additionally, it was found that 8 wk after 1-day starved groups of both C57BL/6J and DBA/2J mice were challenged with ethanol (10%) for 1-day acceptance, they had significantly lower levels of brain [Met]enkephalin compared with their nonalcohol-treated controls. These results suggest that the brain endogenous peptidyl opiates may play a crucial role in alcohol-seeking behavior.
摘要
我们的研究结果表明，在C57BL/6J（嗜酒型）和DBA/2J（非嗜酒型）近交系小鼠品系中，摄入的乙醇（10%）量与脑内[甲硫氨酸]脑啡肽的内源性水平呈负相关。此外，还发现，在C57BL/6J和DBA/2J小鼠的1天饥饿组在接受1天的乙醇（10%）刺激8周后，与未接受酒精处理的对照组相比，它们脑内[甲硫氨酸]脑啡肽水平显著降低。这些结果表明，脑内源性肽类阿片可能在觅酒行为中起关键作用。
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