Schmidt D N, Devaux M A, Biedzinski T M, Sarles H
Scand J Gastroenterol. 1982 Sep;17(6):761-8. doi: 10.3109/00365528209181090.
In non-alcoholic dogs the exocrine pancreatic response to caerulein, but not to urecholine or secretin alone, was increased by atropine. This indicated a pancreatic inhibition triggered by the caerulein stimulation and blocked by atropine. The present aim was to examine whether atropine had a similar action on the caerulein-stimulated pancreatic secretion in dogs submitted to long-term alcohol feeding. Alcohol-fed dogs showed an increased volume and bicarbonate response to submaximal caerulein but a non-modified protein response as compared with the responses before alcohol adaptation. The elevated water and bicarbonate responses were not further enhanced by atropine, which, in contrast, enhanced the responses of normal dogs to such an extent as to equalize their responses with those of the treated dogs. Atropine, 5 micrograms X kg-1 X h-1, enhanced similar protein responses to submaximal caerulein more in normal than in alcohol-fed dogs, but with an eightfold higher atropine dose no enhance was produced in dogs alcohol-fed for 36 months. This dose of atropine still evoked a small and similar enhancement in the normal and 9-month-treated dogs. The enhancing action of atropine on caerulein-stimulated secretion, present in normal dogs, hence diminishes and finally disappears as a result of chronic alcohol feeding.
在非酒精喂养的犬中，阿托品可增强胰腺对外源性蛙皮素的外分泌反应，但对单独的乌拉胆碱或促胰液素无此作用。这表明蛙皮素刺激引发了胰腺抑制，而阿托品可阻断这种抑制。目前的目的是研究阿托品对长期酒精喂养犬的蛙皮素刺激的胰腺分泌是否有类似作用。与酒精适应前的反应相比，酒精喂养的犬对次最大剂量蛙皮素的分泌量和碳酸氢盐反应增加，但蛋白质反应未改变。阿托品并未进一步增强水和碳酸氢盐的升高反应，相反，它使正常犬的反应增强到与经处理犬的反应相当的程度。5微克·千克⁻¹·小时⁻¹的阿托品增强正常犬对次最大剂量蛙皮素的蛋白质反应的程度大于酒精喂养犬，但对于酒精喂养36个月的犬，八倍剂量的阿托品并未产生增强作用。该剂量的阿托品仍能使正常犬和经9个月处理的犬产生小幅度且相似的增强作用。因此，正常犬中存在的阿托品对蛙皮素刺激分泌的增强作用，会因长期酒精喂养而减弱并最终消失。
