Noël-Jorand M C, Schmidt D N, Devaux M A, Sarles H
Biomed Pharmacother. 1983;37(3):129-35.
The persisting modifications induced by repeated intravenous infusion of calcium salts were investigated in five dogs with Thomas fistulae. Five control dogs were also tested. In calcium treated dogs the pancreatic secretion stimulated by graded doses of either caerulein or urecholine showed: a) an increase in the sensitivity of acinar cells to caerulein and urecholine and potentiation by caerulein of the water and bicarbonate response to secretin, in contrast to the decreased sensitivity to secretin alone reported previously. b) an inhibition of water and bicarbonate secretion with urecholine stimulation, c) an inhibition of calcium secretion which was significant with caerulein. These findings could explain the data previously observed on basal pancreatic secretion of calcium treated dogs such as protein hypersecretion with protein precipitates and reduced bicarbonate secretion which are similar to modifications observed in chronic alcoholic dogs and men. These results have a clinical relevance to the understanding of the pathology of chronic pancreatitis.
在五只患有托马斯瘘管的狗身上研究了重复静脉输注钙盐引起的持续变化。还对五只对照狗进行了测试。在接受钙治疗的狗中，由不同剂量的蛙皮素或乌拉胆碱刺激引起的胰腺分泌表现为：a）腺泡细胞对蛙皮素和乌拉胆碱的敏感性增加，并且蛙皮素对水和碳酸氢盐对促胰液素反应有增强作用，这与之前报道的单独对促胰液素敏感性降低形成对比。b）在乌拉胆碱刺激下，水和碳酸氢盐分泌受到抑制，c）在蛙皮素刺激下，钙分泌受到抑制，且这种抑制作用显著。这些发现可以解释之前在接受钙治疗的狗的基础胰腺分泌中观察到的数据，例如蛋白质分泌过多伴有蛋白质沉淀以及碳酸氢盐分泌减少，这些与在慢性酒精中毒的狗和人类中观察到的变化相似。这些结果对于理解慢性胰腺炎的病理学具有临床意义。
