谷氨酸二乙酯可诱导大鼠出现僵住症。这是一种精神分裂症的新模型？
Glutamic acid diethyl ester induces catalepsy in rats. A new model for schizophrenia?
作者信息
Kornhuber J, Fischer E G
出版信息
Neurosci Lett. 1982 Dec 31;34(3):325-9. doi: 10.1016/0304-3940(82)90196-3.
PMID:6891756
Abstract
The glutamate antagonist glutamic acid diethyl ester is found to produce catalepsy in rats, when administered into the lateral ventricle. Since the cerebrospinal fluid content of glutamate is reduced in patients with schizophrenia, the central effects of glutamate antagonists are a possible experimental model for schizophrenia.
摘要
谷氨酸拮抗剂二乙谷氨酸酯被发现，当注入大鼠侧脑室时会使其产生僵住症。由于精神分裂症患者脑脊液中的谷氨酸含量降低，谷氨酸拮抗剂的中枢效应可能是精神分裂症的一种实验模型。
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