Fetterer R, Rew R S, Knight R
Vet Parasitol. 1982 Dec;11(4):309-16. doi: 10.1016/0304-4017(82)90099-1.
Calves were given albendazole (ABZ) daily in feed at levels of 0,3 or 5 mg kg-1 day-1. None of the ABZ treatment levels was significantly effective in reducing Fasciola hepatica burdens. A dose rate of 5 mg kd-1 day-1 did significantly reduce the fecal egg count. Measurements of serum drug levels from calves following a single dose of ABZ showed ABZ levels to be low, but sulfoxide and sulfone metabolites of ABZ were present in (significant) larger quantities. The total available sulfoxide present in calves, however, was much lower than in sheep receiving the same dose of ABZ. Measurements of serum metabolite levels from sheep and calves which were given daily low-level doses of ABZ also indicated that the serum sulfoxide levels of calves were much lower than those of sheep receiving the same ABZ dose. These results indicated that ABZ is not an effective prophylactic treatment for bovine fascioliasis and the differences in efficacy between sheep and cattle correlated with the differences in serum metabolite levels.
给犊牛每日在饲料中添加阿苯达唑（ABZ），添加水平分别为0、3或5毫克/千克体重/天。阿苯达唑的任何处理水平在降低肝片吸虫感染量方面均无显著效果。5毫克/千克体重/天的剂量率确实显著降低了粪便虫卵计数。对单剂量阿苯达唑处理后的犊牛血清药物水平进行测量，结果显示阿苯达唑水平较低，但阿苯达唑的亚砜和砜代谢物含量（显著）更高。然而，犊牛体内存在的总有效亚砜量远低于接受相同剂量阿苯达唑的绵羊。对每日给予低水平阿苯达唑的绵羊和犊牛血清代谢物水平进行测量，结果还表明，犊牛的血清亚砜水平远低于接受相同阿苯达唑剂量的绵羊。这些结果表明，阿苯达唑并非预防牛肝片吸虫病的有效治疗方法，绵羊和牛之间疗效的差异与血清代谢物水平的差异相关。
