[通过瓦尔泽利方法脑内注射多巴胺对甲基苯丙胺刻板行为和运动亢进的影响]

[Effect of dopamine intracerebrally injected by the Valzelli method on methamphetamine-stereotypy and hypermotility].

作者信息

Nomura Y, Ashikari S, Naganuma K, Sakuma K, Watanabe M, Kobayashi M

出版信息

Yakubutsu Seishin Kodo. 1982 Jul;2(1):25-37.

Abstract

In this investigation, the effect of methamphetamine (MAPT) was examined on stereotyped licking and biting and locomotor activity in reserpinized rats which were administered dopamine (DA) intracerebrally. Twenty-four hours after the treatment of reserpine (RE, 1.25 mg/kg ip) or 0.9% saline solution. Wistar male rats received DA (300 micrograms/rat ic) or 0.9% saline solution (5 microliters/rat ic) by Valzelli's method and then 10 min later MAPT (3 mg/kg or 10 mg/kg ip) Stereotyped biting was induced by each dose of MAPT in reserpinized rats. This was suppressed, however, in reserpinized rats given DA. Stereotyped licking was induced by MAPT (10 mg/kg ip) in saline-treated rats. This score did not differ in comparison with the case given DA. Hypermotility was shown by each dose of MAPT in reserpinized and saline-treated rats. This was particularly potentiated in reserpinized rats given DA before the MAPT (10 mg/kg ip), but not any cases of saline-treated rats combined with DA. It is suggested that MAPT-induced stereotyped licking and biting are suppressed in reserpinized rats given DA in a high dose while MAPT-induced hypermotility is potentiated in rats treated as above.

摘要

在本研究中，检测了甲基苯丙胺（MAPT）对脑内注射多巴胺（DA）的利血平化大鼠刻板性舔咬和运动活动的影响。在给予利血平（RE，1.25mg/kg腹腔注射）或0.9%盐溶液处理24小时后，Wistar雄性大鼠通过瓦尔泽利方法接受DA（300微克/大鼠脑内注射）或0.9%盐溶液（5微升/大鼠脑内注射），然后10分钟后给予MAPT（3mg/kg或10mg/kg腹腔注射）。各剂量的MAPT均可诱导利血平化大鼠出现刻板性咬。然而，在给予DA的利血平化大鼠中，这种刻板性咬受到抑制。在盐水处理的大鼠中，MAPT（10mg/kg腹腔注射）可诱导刻板性舔。与给予DA的情况相比，该评分无差异。各剂量的MAPT均可使利血平化和盐水处理的大鼠出现运动亢进。在MAPT（10mg/kg腹腔注射）前给予DA的利血平化大鼠中，这种运动亢进尤为明显，但在任何盐水处理大鼠与DA联合的情况下均未出现。提示在高剂量给予DA的利血平化大鼠中，MAPT诱导的刻板性舔咬受到抑制，而在上述处理的大鼠中，MAPT诱导的运动亢进增强。