Berman J J, Rice J M, Reddick R
Arch Pathol Lab Med. 1980 Apr;104(4):187-91.
Thirty male Sprague-Dawley rats were given a single intravenous injection of methyl(acetoxymethyl)nitrosamine. Primary endocardial tumors developed in ten rats. By light and electron microscopy, the tumors had many of the typical features of schwannomas (neurinomas) in rats. Tumors were composed of masses of elongated cells surrounded by a fine reticulin network, occasionally forming Verocay bodies. Basement membrane was observed on the external surfaces of tumor cells, which had convoluted plasma membranes. To our knowledge, this is the first report of a spontaneous endocardial schwannoma in a rat. The literature addressing endocardial tumors in rodents and man is discussed, and criteria for distinguishing this neoplastic entity from other tumors and non-neoplastic endocardial proliferations are described.
给30只雄性斯普拉格-道利大鼠单次静脉注射甲基（乙酰氧基甲基）亚硝胺。10只大鼠发生了原发性心内膜肿瘤。通过光学显微镜和电子显微镜观察，这些肿瘤具有大鼠雪旺瘤（神经鞘瘤）的许多典型特征。肿瘤由细长细胞团组成，周围有精细的网状纤维网络，偶尔形成Verocay小体。在肿瘤细胞的外表面观察到基底膜，肿瘤细胞的质膜呈卷曲状。据我们所知，这是大鼠自发性心内膜雪旺瘤的首次报道。本文讨论了啮齿动物和人类心内膜肿瘤的相关文献，并描述了将这种肿瘤实体与其他肿瘤及非肿瘤性心内膜增生相区分的标准。
